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VOLUME 1 , ISSUE 1 ( January-June, 2018 ) > List of Articles

STUDENT RESEARCH

Study of Correlation between Vitamin ‘D’ Deficiency and Anti-Thyroperoxidase Antibodies in Autoimmune Thyroid Diseases

Preeti Patni, Tanu Choudhary, Tarun Sekhri, Ratnesh Kanwar, Neeta Uniyal

Keywords : Autoimmune thyroid disease (AITD), Vitamin D,Antithyroid peroxidase

Citation Information : Patni P, Choudhary T, Sekhri T, Kanwar R, Uniyal N. Study of Correlation between Vitamin ‘D’ Deficiency and Anti-Thyroperoxidase Antibodies in Autoimmune Thyroid Diseases. Journal of Medical Academics 2018; 1 (1):10-14.

DOI: 10.5005/jp-journals-10070-0003

License: CC BY-ND 3.0

Published Online: 00-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: The aim of this study is to explore the relationship between vitamin D levels and antithyroid peroxidase antibodies (ATPO Ab) in recently diagnosed patients of autoimmune thyroid disease (AITD). Material and methods: A total of 138 and 30 recently diagnosed female patients of Hashimoto\'s thyroiditis (HT) and graves\' disease (GD) along with 46 healthy females as controls were enrolled in groups I, II and III respectively. In this study 25OHD, PTH, calcium, and thyroid autoantibody [anti-thyroid peroxidase (anti-TPO)] levels were evaluated for all subjects (n = 214). Results: Lower serum 25OHD levels were present in groups I and II patients (12.6 ± 9.04 ng/mL, 10.6 ± 5.4 ng/mL respectively) than in group III subjects (22.8 ± 6.4 ng/m}L), (p < 0.00001). Although serum 25OHD levels inversely correlated with anti-TPO (r = –0.32, p = 0.0001) and parathormone (PTH) (r = –0.27, p = 0.0049) but no significant correlation of serum 25OHD levels was found with TSH (r = 0.04, p = 0.07) and FT4 levels (r = 0.02, p = 0.6). Hypothyroid patients (Group I) had higher anti-TPO levels than patient with GD and controls (groups II and III) (p < 0.0001). Conclusion: Our study demonstrated that lower vitamin D levels are found in AITD patients in at present. Severity and prevalence of vitamin D deficiency are higher in GD patients than hypothyroid patients. An inverse correlation was found in this study between antithyroid peroxidase antibodies (ATPO Ab) and vitamin D levels. We may propose that vitamin D deficiency is one of the potential factors in the pathogenesis of autoimmune thyroid disorders. Clinical significance: More larger studies, to evaluate the role of Vitamin D in pathogenesis of AITD and beneficial effect of its supplementation in treatment, are needed.


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  1. Dayan, Dayan, Colin M; Dayan, Colin M.; Gilbert H. Daniels (1996). “Chronic Autoimmune Thyroiditis”. The New England Journal of Medicine. 335 (2):99-107.
  2. Baeke F, Takiishi T, Korf H, et al. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010;10:482–496.
  3. Cutolo M, Otsa K, Uprus M, et al. Vitamin D in rheumatoid arthritis. Autoimmun Rev. 2007;7:59-64.
  4. Mok CC. Vitamin D and systemic lupus erythematosus: an update. Expert Rev Clin Immunol. 2013;9:453-463.
  5. Iruretagoyena M, Hirigoyen D, Naves R, Burgos PI. Immune response modulation by vitamin D: role in systemic lupus erythematosus. Front Immunol. 2015;6:513.
  6. Feng, M., Li, H., Chen, SF. et al. Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine 2013;43:318-326.
  7. Kmie P, Sworczak K Vitamin D in thyroid disorders. Exp. Clin. Endocrinol. Diabetes. 2015;123:386-393
  8. Prietl B, Treiber G, Pieber TR, Amrein K Vitamin D and immune function. Nutrients. 2013;5:2502-2521
  9. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press; 2010.
  10. Elizabeth A, Brulé Danielle, Cindy D, Krista A, Peter WF, Friedl Karl E, et al. Dietary Reference Intakes for vitamin D: justification for a review of the 1997 values. Am J Clin Nutr. 2009;89(3):719-727.
  11. Kim D. The Role of Vitamin D in Thyroid Diseases. International Journal of Molecular Sciences. 2017;18(9):1949.
  12. Tamer G, Arik S, Tamer I, Coksert D. Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid. 2011;21: 891-896.
  13. Bozkurt NC, Karbek B, Ucan B, et al. The association between severity of vitamin D deficiency and Hashimoto's thyroiditis. Endocr Pract. 2013;19:479-484.
  14. Kivity S, Agmon-Levin N, Zisappl M, et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011;8:243- 247.
  15. Unal AD, Tarcin O, Parildar H, Cigerli O, Eroglu H, Demirag NG. Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis. Cent Eur J Immunol. 2014;39(4):493-7.
  16. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266- 281.
  17. Misharin A, Hewison M, Chen CR, et al. Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. Endocrinology. 2009;150:1051-1060.
  18. Kozai M, Yamamoto H, Ishiguro M, et al. Thyroid hormones decrease plasma 1alpha,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxy vitamin D3 1alpha-hydroxylase gene (CYP27B1) Endocrinology. 2013;154:609-622.
  19. Klecha AJ, Barreiro Arcos ML, Frick L, Genaro AM, Cremaschi G. Immune-endocrine interactions in autoimmune thyroid diseases. Neuroimmunomodulation. 2008;15:68-75
  20. McLachlan SM, Nagayama Y, Rapoport B. Insight into Graves' hyperthyroidism from animal models. Endocr Rev. 2005;26:800-832.
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