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VOLUME 1 , ISSUE 1 ( January-June, 2018 ) > List of Articles


Air Pollution and Cytokines

Poonam Agrawal, Manu Krishnan, Richa Dixit

Keywords : Air pollution, Cytokines, Inflammation.

Citation Information : Agrawal P, Krishnan M, Dixit R. Air Pollution and Cytokines. Journal of Medical Academics 2018; 1 (1):43-49.

DOI: 10.5005/jp-journals-10070-0008

License: NA

Published Online: 01-04-2018

Copyright Statement:  NA


Aim: The present review is aimed to assess the role of inflammatory mediators in the initiation and progression of the disorders, related to air pollution, with a special focus on cytokines. Background: Air pollution adversely affects human health. The outdoor and indoor pollution accounts for approximately 4 million deaths every year. The major pollutants include gaseous compounds, polycyclic aromatic hydrocarbons (PAH) and particulate matter (PM). Epidemiologic data shows the increase in the incidence of cardiopulmonary and central nervous system disorders on exposure of the pollutants and how do they aggravate the pre-existing disease conditions. Also, it contributes to the higher rate in cancer prevalence also. Review results: Numerous studies were carried out in delineating the underlying pathological changes of these diseases due to pollution. The suggestive mechanisms include the local and systemic inflammatory response and bone marrow stimulation elicited as a result of the entry of the toxic compounds. The oxidative stress developed also is said to be a contributing factor. The multiple interactions of a broad range of compounds like, cytokines, growth factors, adhesion molecules, reactive oxygen species, and acute phase proteins are also involved in the reactions. Conclusion: Multiple interrelated molecular pathways of inflammation are stimulated as a result of air pollution and which in turn leads to the secretion of the mediators and effector molecules. Cytokines are significant intermediaries of both the innate and the adaptive immune responses. These compounds take a m ajor position in the events in pathogenesis. Clinical significance: The concentrations of cytokines are seen altered in circulation and tissues. Hence, these may have the potential in considering as markers for evaluating adverse effects of air pollution.

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  1. World Health Organization. Ambient air pollution: health impacts [Internet]. Geneva: World Health Organization; May 2018. Available from
  2. World Health Organization. Air pollution [Internet]. Geneva: World Health Organization; May 2018. Available from
  3. TERI. Air Pollution and Health. Discussion Paper by the Energy and Resources Institute. New Delhi: TERI; 2015. Available from
  4. Jiang XQ, Mei XD, Feng D. Air pollution and chronic air way diseases:what should people know and do? J Thorac Dis. 2016 Jan;8(1): e31-40.
  5. Kelly FJ, Fussell JC. Air pollution and airway disease. Clin Exp Allergy. 2011 Aug; 41(8): 1059-1071.
  6. Brockmeyer S, D'Angiulli A. How air pollution alters brain development: the role of neuroinflammation. Transl Neurosci. 2016 Mar; 7(1):24-30.
  7. Hadley MB, Vedanthan R, Fuster V. Air pollution and cardiovascular disease: a window of opportunity. Nat Rev Cardiol. 2018 Apr; 15(4). 193-194.
  8. Rees N. Danger in the air: How air pollution can affect brain development in young children. New York: United Nations Children's Fund (UNICEF); 2017. Available from https://www. in the Air.pdf.
  9. Simoni M, Baldacci S, Maio S, Cerrai S, Sarno G, Viegi G. Adverse effects of outdoor pollution in the elderly. J Thorac Dis. 2015 Jan;7(1):34-45.
  10. Straif K, Cohen A, Samet J. Air Pollution and Cancer. France: International Agency for Research on Cancer; 2013. pp 123-149.
  11. Bolden AL, Schultz K, Pelch KE, Kwiatkowski CF. Exploring the endocrine activity of air pollutants associated with unconventional oil and gas extraction. Environ Health. 2018 Mar;17(1):26-33.
  12. Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S, et al. Air pollution impairs cognition, provokes depressive like behaviours and alters hippocampal cytokine expression and morphology. Mol Psychiatry. 2011 Oct;16(10):987-995.
  13. Carre J, Gatimel N, Moreau J, Parinaud J, Leandri R. Does air pollution play role in infertility?: a systematic review. Environ Health. 2017 Jul;16(1):82.
  14. Praveen K. Investigating Possible. Effects of Environmental Pollution on Dental Caries Prevalence. Masters thesis, Indian Institute of Science Education and Research Kolkata. 2014.
  15. Dobreva ZG, Kostadinova GS, Popov BN, Petkov GS, Stanilova SA. Pro-inflammatory and anti-inflammatory cytokines in adolescents from south east Bulgarian cities with different levels of air pollution. Toxicol Ind Health. Dec;31(12):1210-1217.
  16. Becker S, Mundandhara S, Devlin RB, Madden M. Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies. Toxicol Appl Pharmacol. 2005 Sept;207(2 Suppl):S269–S275.
  17. Zhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007 Spring;45(2):27-37.
  18. Kindt T, Goldsby R, Osborne B, Kuby J. Kuby immunology. 6th ed. New York: W.H. Freeman; 2007.
  19. Hackett T-L, Holloway R, Holgate ST, Warner JA. Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study. Respir Res. 2008 May;9:47.
  20. Ljungman P, Bellander T, Schneider A, Breitner S, Forastiere F, Hampel R, et al. Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphisms. Environ Health Perspect. 2009 Sept;117(9):1373.
  21. Liu YW, Chen CC, Tseng HP, Chang WC. Lipopolysaccharide- induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-kBinduced CCAAT/enhancerbinding protein delta in mouse macrophages. Cell Signal. 2006 Sep;18(9):1492-1500.
  22. Arbex MA, Santos UP, Martins LC, Saldiva PHN, Pereira LAA, Braga ALF. Air pollution and respiratory system. J Bras Pneumol. 2012 Aug; 38(5):643-655.
  23. Downs SH, Schindler C, Liu LJ, Keidel D, Bayer-Oglesby L, Brutsche MH, et al. Reduced exposure to PM10 and attenuated age-related decline in lung function. N Engl J Med. 2007 Dec; 357(23):2338-2347.
  24. Godleski JJ, Clarke RW, Coull BA. Composition of inhaled urban air particles determines acute pulmonary responses. Ann Occup Hyg. 2002;46(Suppl 1):419-424.
  25. Becker S, Soukup JM, Gilmour MI, Devlin RB. Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production. Toxicol Appl Pharmacol 1996;141:637-648.
  26. Van Eeden SF, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T, et al. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM10). Am J Respir Crit Care Med. 2001 Sep;164(5):826- 830.
  27. Audi C, Baiz N, Maesano CN, Ramousse O, Reboulleau D, Magnan A, et al. Serum cytokine levels related to exposure to volatile organic compounds and PM2.5 in dwelling and workplaces in French farmers-a mechanism to explain non-smoking COPD. Int J Chron Obstruct Pulmon Dis. 2017 May;12:1363-1374.
  28. Du Y, Xu X, Chu M, Guo Y, Wang J. Air particulate matter and cardiovascular disease: the epidemiological, biomedical and clinical evidence. J Thorac Dis. 2016 Jan;8(1):e8-19.
  29. Poursafa P, Kelishadi R. Air pollution, platelet activation and atherosclerosis. Inflamm Allergy Drug Targets. 2010 Dec; 9(5): 387-392.
  30. Pope CA, Bhatnagar A, McCracken JP, Abplanalp W, Conklin DJ, O;Toole T. Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ Res. Nov;119(11):1204-1214.
  31. Ruckerl R, Hampel R, Breitner S, Cyrys J, Kraus U, Carter J, et al. Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations. Environ Int. 2014 Sep;70:32-49.
  32. Genc S, Zadeoglulari Z, Fuss SH, Genc K. The adverse effects of air pollution on the nervous system. Journal of Toxicology. 2012;2012:1-23
  33. Block ML, Calderon-Garciduenas L. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci. 2009 Sep;32(9):506-516.
  34. Zanchi AC, Venturini CD, Saiki M, Nascimento Saldiva PH, Tannhauser Barros HM, Rhoden C R. “Chronic nasal instillation of residual-oil fly ash (ROFA) induces brain lipid peroxidation and behavioral changes in rats,” Inhalation Toxicology. 2008;20(9): pp. 795-800.
  35. University of Birmingham. Exposure to particulate air pollutants associated with numerous cancers [Internet]. Hong Kong. University of Birmingham; Apr 2016. Available from
  36. Manzetti S, Anderson O. Biochemical and physiological effects from exhaust emissions. A review of literature. Pathophysiology. 2016 Dec;23(4):285-293.
  37. Mostafavi N, Vlaanderen J, Chadeau-Hyam M. Beelen R, Modig L, Palli D. Inflammatory markers in relation to long term air pollution. Environ Int. 2015 Aug;81:1-7.
  38. Mehrbani SP, Babaloo Z, Jamali Z, Abdollahian T, Eslami H, Sobhani N. Effect of air pollution on salivary interleukin- 8 levels in Children. World Journal of Dentistry, 2016 Oct;7(4):175-178.
  39. Amsen D, de Visser KE, Town T. Approaches to determine expression of inflammatory cytokines. Methods Mol Biol. 2009;511:107-142.
  40. Kupcova Skalnikova H, Cizkova J, Cervenka J, Vodicka P. Advances in proteomic techniques for cytokine analysis: Focus on melanoma research. Int J Mol Sci. 2017 Dec;18(12): e2697.
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