Journal of Medical Academics

Register      Login

VOLUME 1 , ISSUE 2 ( July-December, 2018 ) > List of Articles


Effect of Artificial Sweeteners on the Blood Glucose Concentration

Seema Saraswathy

Keywords : Artificial sweeteners, Aspartame, Saccharine, Sucralose, Stevia

Citation Information : Saraswathy S. Effect of Artificial Sweeteners on the Blood Glucose Concentration. Journal of Medical Academics 2018; 1 (2):81-85.

DOI: 10.5005/jp-journals-10070-0017

License: NA

Published Online: 01-12-2018

Copyright Statement:  NA


Diabetes mellitus (DM) becoming pandemic and India is toward the capital of DM. Artificial sweeteners were extensively introduced into our diet with the intention of reducing caloric intake/ weight management. Several studies investigated its benefits as well as the health issues. Aim: The present study was aimed to evaluate whether there is any change in blood sugar level after consuming artificial sweeteners. It also focused to determine artificial sweetener with less effect on blood sugar level. Materials and methods: Healthy individuals (n = 30) of 18–25 years with normal body mass index (BMI) (19–25 kg/m2) and without any preexisting diseases were selected for the study. Fasting blood specimens and 1 hour after intake of glucose and artificial sweeteners, aspartame sucralose, stevia and saccharin (equivalent to 15 g of sugar with 200 mL of water) were collected. The significance of levels of glucose was studied with student's t-test and one-way analysis of variance (ANOVA). Results: The mean fasting blood glucose concentration of all participants was in the range of 71.71 ± 8.27 to 80.94 ± 7.30 mg%. The mean glucose level after one hr of intake of glucose was 80.42 ± 8.97 mg%, and that of artificial sweeteners ranged from 74.42 ± 8.34 to 83.19 ± 5.62. A statistically significant decrease (p <0.001) compared to the glucose intake has been observed in the difference in the glucose levels between the two samples. There was minimal increase in the blood glucose concentration after intake of the artificial sweeteners. Conclusion: There was increase in the blood glucose level after the intake of artificial sweeteners and it was less compared to the glucose consumption. There was no difference in the values among the four artificial sweeteners, saccharine, aspartame, sucralose, and stevia. Stevia, being a natural product and having less side effect as compared to other artificial sweeteners, it can be suggested for incorporating as sugar substitute in dietary products.

PDF Share
  1. Sharma A, Amarnath S, Thulasimani M, Ramaswamy S. Artificial sweeteners as a sugar substitute: Are they really safe? Indian J Pharmacol. 2016;48(3):237-240.
  2. Lange FT, Scheurer M, Brauch HJ. Artificial sweeteners–a recently recognized class of emerging environmental contaminants: a review. Analytical and Bioanalytical Chemistry. 2012;403(9):2503-2518..
  3. Okoduwa SIR, Ebiloma GU, Baba J, Ajide S. The metabolism and toxicology of saccharin. Info health awareness article. 2013;1(1):14-19.
  4. Kroger M, Meister K, Kava R. Low calorie sweetners and other sugar substitutes: A review of the safety issues. Compr Rev Food Sci Food Saf. 2006;5:35-47.
  5. Lin SY, Cheng YD. Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system. Food Additives and Contaminants. 2000;17(10):821-827.
  6. Sims J, Roberts A, Daniel JW, Renwick AG. The metabolic fate of sucralose in rats. Food and chemical Toxicology. 2000;38:115-121.
  7. Geuns JM. Stevioside. Phytochemistry. 2007;64:913-921.
  8. Prakash I, Chaturvedula VS. Steviol Glycosides: Natural Non-Caloric Sweeteners. Sweeteners: Pharmacology, Biotechnology, and Applications. 2017:1-28.
  9. Tandel KR. Sugar substitutes: Health controversy over perceived benefits. J Pharmacol Pharmacother. 2011; 2(4):236-243.
  10. Renwick AG. The intake of intense sweeteners–An update review. Food Addit Contam. 2006;23:327-338.
  11. Gardner C, Wylie-Rosett J, Gidding SS, Steffen LM, Johnson RK, Reader D, et al. Nonnutritive sweeteners: Current use and health perspectives: A scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care. 2012;35:1798-1808.
  12. Hampton T. Sugar substitutes linked to weight gain. JAMA. 2008;299:2137-2138.
  13. Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, et al. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite. 2010;55(1):37-43.
  14. Schiffman SS, Rother KI. Sucralose, a synthetic organochlorine sweetener: Overview of biological issues.
  15. Schiffman SS, Abou-Donia MB. Sucralose revisited: Rebuttal of two papers about Splenda safety. Regulatory toxicology and pharmacology. 2012;63(3):505-508.
  16. Malaisse WJ, Vanonderbergen A, Louchami K, Jijakli H, Malaisse-Lagae F. Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets. Cell Signal. 1998;10(10):727-733.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.