Journal of Medical Academics

Register      Login

VOLUME 1 , ISSUE 2 ( July-December, 2018 ) > List of Articles


Practice Changing Continuing Education: A Critical Review of Neurological Complications in Acute Pancreatitis

Niraj Kumar, Mamadur MR Shankar

Keywords : Acute pancreatitis, Metabolic encephalopathy, Pancreatic encephalopathy, Wernicke encephalopathy

Citation Information : Kumar N, Shankar MM. Practice Changing Continuing Education: A Critical Review of Neurological Complications in Acute Pancreatitis. Journal of Medical Academics 2018; 1 (2):109-110.

DOI: 10.5005/jp-journals-10070-0022

License: NA

Published Online: 01-12-2018

Copyright Statement:  NA


This uncommon syndrome of pancreatic encephalopathy was first described in 1923. A manifestation of multiple organ dysfunction syndromes, generally occurs in the early stage of severe acute pancreatitis and carries high mortality of up to 57% and more. The syndrome must be distinguished from Wernicke encephalopathy, which may follow as a part of neurological complications in the last or recovery phase of acute pancreatitis, and occurs as a result of long fasting, hyperemesis and total parenteral nutrition without thiamine. Poorly recognized by clinicians, a large dose of vitamin B1 is effective in the management of Wernicke encephalopathy. In view of above the present review draws attention to the challenging and lesser recognized complications of acute pancreatitis and briefly dwells on their pathogenesis and management.

PDF Share
  1. Katramados A, Varelas P. Encephalopathy. In: Torbey M, editor. Neurocritical Care. Cambridge: Cambridge University Press; 2010. p. 220-226.
  2. Sun GH, Yang YS, Liu QS, Cheng LF, Huang XS. Pancreatic encephalopathy and Wernicke encephalopathy in association with acute pancreatitis: A clinical study. World J Gastroenterol 2006;12:4224-4227.
  3. Ding X, Liu CA, Gong JP, Li SW. Pancreatic encephalopathy in 24 patients with severe acute pancreatitis. Hepatobiliary Pancreat Dis Int 2004;3:608-611.
  4. Weathers AL, Lewis SL. Rare and unusual... or are they? Less commonly diagnosed encephalopathies associated with systemic disease. Semin Neurol 2009;29:136-153.
  5. Sharma V, Sharma R, Rana SS, Bhasin DK. Pancreatic encephalopathy: An unusual cause of asterixis. JOP 2014;15:383-384.
  6. Sharf B, Bental E. Pancreatic encephalopathy. J Neurol Neurosurg Psychiatry 1971;34:357-361.
  7. Zhang XP, Tian H. Pathogenesis of pancreatic encephalopathy in severe acute pancreatitis. Hepatobiliary Pancreat Dis Int 2007;6:134-140.
  8. Rothermich NO, Von Haam E. Pancreatic encephalopathy. J Clin Endocrinol Metab 1941;1:872-881.
  9. Ramanathan RS, Ahluwalia T. Acute necrotizing pancreatitis leading to pancreatic encephalopathy in a patient undergoing long-term continuous ambulatory peritoneal dialysis. J Acad Med Sci 2012;2:85-87.
  10. Lu XS, Qiu F, Li YX, Li JQ, Fan QQ, Zhou RG. Effect of lowermolecular weight heparin in the prevention of pancreatic encephalopathy in the patient with severe acute pancreatitis. Pancreas. 2010 May 1;39(4):516-519.
  11. Yang YL, Li JP, Li KZ, Dou KF. Tumor necrosis factor á antibody prevents brain damage of rats with acute necrotizing pancreatitis. World Journal of Gastroenterology: WJG. 2004 Oct 1;10(19):2898-2900.
  12. Jha RK, Ma Q, Sha H, Palikhe M. Protective effect of resveratrol in severe acute pancreatitis-induced brain injury. Pancreas. 2009 Nov 1;38(8):947-953.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.