Journal of Medical Academics

Register      Login

VOLUME 3 , ISSUE 2 ( July-December, 2020 ) > List of Articles

Original Article

Role of Tissue Glue in Overlay Tympanoplasty vs Conventional Overlay Method

Surendra V Pimparkar, Ashwani Sethi, Avinash Das, Himanshu Joshi

Citation Information : Pimparkar SV, Sethi A, Das A, Joshi H. Role of Tissue Glue in Overlay Tympanoplasty vs Conventional Overlay Method. Journal of Medical Academics 2020; 3 (2):33-37.

DOI: 10.5005/jp-journals-10070-0058

License: CC BY-NC 4.0

Published Online: 01-04-2021

Copyright Statement:  Copyright © 2020; The Author(s).


Purpose: The purpose of this research is to study the role of tissue glue (TISSEL) in overlay tympanoplasty when compared with the conventional overlay method. Study design: A prospective randomized comparative study was carried out at the ENT department of Base Hospital, Delhi, in which 60 patients with dry central perforation underwent overlay tympanoplasty. Out of these, 30 underwent conventional overlay tympanoplasty (control) and in the rest of the 30, overlay tympanoplasty was done with the use of tissue glue (cases). Results: Graft take-up rate in control is 90% and in cases 96.7% (p > 0.05). Hearing improvement within 20 dB of A–B gap (at 03 months) in control is 86.70 and 96.70% in cases (p > 0.05). Early hearing improvement (at 6 weeks) in cases was better when compared with the control (p < 0.05). The complication rate in cases is 10% with residual perforation in 01 patient, while that in control is 16.66% with residual perforation in 03 patients (p > 0.05). Conclusion: Graft take-up rate in hearing improvement was found to be better in overlay tympanoplasty with the use of tissue glue when compared with the conventional method with no statistically significant difference. The only significant advantage with the TISSEL group was found to be an early hearing improvement at 6 weeks. Tissue glue (TISSEL) was found to be safe and effective.

  1. Reconstruction of middle ear. In: Kerr AG, Booth JB, ed. Scott-Brown's Otolaryngology. 6th edn, Great Britain: Butterworth Heinmann; 1997. pp. 1–6.
  2. Myringoplasty. AMA Arch Otolaryngol 1960;71:399-404. DOI: 10.1001/archotol.1960.03770030041009.
  3. Healing of wounds and scar formation under the coagulation factor XII. Arch Otorhinolaryngol 1979;222(4):41-45.
  4. The repair of severed peripheral nerves by means of fibrin seal. Clinical experience and results. Eur Surg Res 1979;11:98-99.
  5. Fibrin glue in craniofacial surgery. J Craniofac Surg 1990;1(1):2-4. DOI: 10.1097/00001665-199001000-00008.
  6. Tissue adhesives in otorhinolaryngology. GMS Curr Top Otorhinolaryngol Head Neck Surg 2009; 9
  7. A method of preparation of fibrin glue. J Laryngol Otol 1987;101(11):1182-1186. DOI: 10.1017/S0022215100103469.
  8. The glassgow benefit plot: a new method of reporting benefits from middle ear surgery. Laryngoscope 1991;101(2):180-185. DOI: 10.1288/00005537-199102000-00014.
  9. Tympanoplasty: should grafts be placed medial or lateral to the tympanic membrane. Laryngoscope 1972;82(8):1425-1430. DOI: 10.1288/00005537-197208000-00005.
  10. Myringoplasty. A review of 472 cases. Ann Oto Rhinol Laryngol 1980;89(4 pt 1):331-334. DOI: 10.1177/000348948008900407.
  11. 3rd Tympanic membrane grafting with fascia: Overlay vs underlay technique. Laryngoscope 1973;83(5):754-770. DOI: 10.1288/00005537-197305000-00011.
  12. Overlay vs underlay tympanoplasty. Part II: the study. Laryngosscope 1997;107(12 pt 2):26-36. DOI: 10.1097/00005537-199712001-00002.
  13. Comparative study of underlay and overlay technique of myringoplasty in large and subtotal perforations of the tympanic membrane. J Laryngol Otol 2003;117(6):444-448. DOI: 10.1258/002221503321892262.
  14. How I do it-otology and neurotology, a specific issue and its solution autologous tissue seal in myringoplasty. Laryngoscope 1987;97(3 pt 1):370-371.
  15. Tympanoplasty without use of gelfoam in the middle ear. Iranian J Otorhinolaryngol 2008;20(52):65-70.
  16. Closure of recurrent perforations of the tympanic membrane. HNO 1979;27(12):413-415.
  17. Role of tissue adhesive in otorhinolaryngology. Ototlaryngol Online J 2012;2(3):42. DOI: 10.5455/jorl.51-1335890250.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.