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VOLUME 4 , ISSUE 1 ( January-June, 2021 ) > List of Articles


Pandrug-resistant Infections

Dr Novy Gupte, Sapna Pradhan

Keywords : Acinetobacter, Antimicrobial resistance, Antimicrobial stewardship, Enterococcus, Extensive-drug resistance, Klebsiella pneumoniae, Pandrug resistance, Proteus, Pseudomonas aeruginosa, Staphylococcus aureus

Citation Information : Gupte DN, Pradhan S. Pandrug-resistant Infections. Journal of Medical Academics 2021; 4 (1):28-29.

DOI: 10.5005/jp-journals-10070-0065

License: CC BY-NC 4.0

Published Online: 01-12-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Background: Increasing antibiotic resistance, usually from irrational pharmacotherapy, poses a grave challenge to clinicians in managing multidrug-resistance infections. Aim and objective: To focus attention on the rising incidence of pandrug-resistant infections, related issues and concerns, and their containment. Materials and methods: The short communication is prompted by the recently reported in vitro sensitivity of gram-negative bacteria to a combination of ceftriaxone + sulbactam + EDTA. Appropriate observations from literature are cited to complement the outcome of the said study. Results: Pandrug resistance (PDR) is defined as a non-susceptibility of the bacteria to all antimicrobial agents in all antimicrobial categories. This is not true that it is restricted to only gram-negative bacteria. Staphylococcal aureus, a gram-positive bacteria, may too develop such resistance. The in vitro sensitivity observations do not necessarily get reflected in actual clinical effectiveness and efficacy. Therapy is a herculean task. Judicious use of antibiotics and strict infection control measures, preferably as a part of an antibiotic stewardship program, are mandatory to reduce the prevalence of PDR, nay the drug resistance as such. Conclusion: Pandrug resistance, meaning resistance to all classes of antibiotics, can develop not only in the case of gram-negative bacteria but also gram-positive bacteria, like S. aureus. It is best prevented rather than treated. Clinical significance: Implementation of the antibiotic stewardship program, mainly comprising rational antibiotic therapy, has the potentials to go a long way in safeguarding against PDR, nay antibiotic resistance as such.

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  2. Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria. Clin Microb Infect 2011;8(3):268–281.
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  4. Gupte N. Antimicrobial stewardship: the crying need of the time. EC Pharama Toxicol (London) 2020;8(8):1–2.
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