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VOLUME 1 , ISSUE 1 ( January-June, 2018 ) > List of Articles

CASE REPORT

Rifampicin Induced Nephrotic Syndrome: A Case Report

Sumit Arora, Satish Mendonca, Arun Natarajan

Keywords : Rifampicin, Nephrotic syndrome, Minimal change disease

Citation Information : Arora S, Mendonca S, Natarajan A. Rifampicin Induced Nephrotic Syndrome: A Case Report. Journal of Medical Academics 2018; 1 (1):72-73.

DOI: 10.5005/jp-journals-10070-0015

License: NA

Published Online: 01-04-2018

Copyright Statement:  NA


Abstract

Introduction: Rifampicin is a potent antitubercular drug used in the treatment of tuberculosis (TB). It is known to cause nephrotoxicity of which nephrotic syndrome is a less common though well-known manifestation. Case report: We present a case of rifampicin induced minimal change disease in a patient with HIV and TB who responded completely to the withdrawal of drug alone and did not require any specific therapy for nephrotic syndrome.


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  1. Waldman M, Crew RJ, Valeri A, Busch J, Stokes B, Markowitz G, et al. Adult minimal-change disease: clinical characteristics, treatment, and outcomes. Clin J Am Soc Nephrol. 2007;2:445-453.
  2. Covic A, Goldsmith DJ, Segall L, Stoicescu C, Lungu S, Volovat C, et al. Rifampicin-induced acute renal failure: a series of 60 patients. Nephrol Dial Transplant. 1998;13:924-929.
  3. Muthukumar T, Jayakumar M, Fernando EM, Muthusethupathi MA. Acute renal failure due to rifampicin: a study of 25 patients. Am J Kidney Dis. 2002;40:690-696.
  4. De Vriese AS, Robbrecht DL, Vanholder RC, Vogelaers DP, Lameire NH. Rifampicin-associated acute renal failure: pathophysiologic, immunologic, and clinical features. Am J Kidney Dis. 1998;31:108-115.
  5. Kohno K, Mizuta Y, Yoshida T, Watanabe H, Nishida H, Fukami K, et al. Minimal change nephrotic syndrome asso- ciated with rifampicin treatment. Nephrol Dial Transplant. 2000;15:1056-1059.
  6. Neugarten J, Gallo GR, Baldwin DS. Rifampin-induced nephrotic syndrome and acute interstitial nephritis. Am J Nephrol. 1983;3:38-42.
  7. Tada T, Ohara A, Nagai Y, Otani M, Ger YC, Kawamura S. A case report of nephrotic syndrome associated with rifampicin therapy. Nihon Jinzo Gakkai Shi. 1995;37:145-150.
  8. Rekha VV, Santha T, Jawahar MS. Rifampicin-induced renal toxicity during retreatment of patients with pulmonary tuberculosis. J Assoc Physicians India. 2005;53:811-813.
  9. Murray AN, Cassidy MJ, Templecamp C. Rapidly progressive glomerulonephritis associated with rifampicin therapy for pulmonary tuberculosis. Nephron. 1987;46:373-376.
  10. Yoshioka K, Satake N, Kasamatsu Y, Nakamura Y, Shikata N. Rapidly progressive glomerulonephritis due to rifampicin therapy. Nephron. 2002;90:116-118.
  11. Black DA, Rose G, Brewer DB. Controlled trial of prednisone in adult patients with the nephrotic syndrome. Br Med J. 1970;3:421-426.
  12. Glassock RJ. Secondary minimal change disease. Nephrol Dial Transplant. 2003;18(Supply 6):vi52-vi58.
  13. Dong HP, Sul AL, Hyeon JJ, Tae HY, Shin-Wook K et al. Rifampicin induced minimal change disease is improved after cessation of rifampicin without steroid therapy. Yonsei Med J. 2015;56(2):582-585.
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